A long-abandoned home for the mentally ill, recently re-opened by the “research and charity” branch of the transnational Murkoff Corporation, the asylum has been operating in strict secrecy… until now. Therefore, this multiple-identity Fenton-like agent could provide an appreciable reference value for the design of atomically precise CDT agents.In the remote mountains of Colorado, horrors wait inside Mount Massive Asylum. More importantly, in vivo results further demonstrate that VBio-Cu ICu II could significantly inhibit tumor growth without obvious damage toward major organs. Furthermore, the Cu II in VBio-Cu ICu II was available for successive ˙OH production via a Cu I/Cu II-circulation strategy under a GSH-rich tumor site, thereby improving catalytic efficiency. Meanwhile, the Cu I metal center could be used as a Fenton-like agent to generate ˙OH. Owing to the obvious cell selectivity discrepancy of biotin towards normal and cancerous cells, VBio-Cu ICu II was able to preferentially accumulate in tumor cells. This targeted Fenton-like agent, VBio-Cu ICu II, is constructed from a hydroxyl radical-producible Cu I ion, a Cu II center as a GSH depletor for an augmented CDT effect, and a biotin moiety as a cancer-targeting unit. Compared to traditional CDT nanomaterials, herein, an atomically-precise biotinylated Cu( I/ II) complex ♼H 3OH (VBio = deprotonated O-vanillin biotinylhydrazone), denoted VBio-Cu ICu II, was rationally designed and synthesized successfully. Chemodynamic therapy (CDT), in which highly toxic hydroxyl radicals (˙OH) could be triggered by a Fenton or Fenton-like reaction to kill cancer cells, has emerged recently.

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